منابع مشابه
Acute renal failure and nephrotoxic drugs.
abnormal retention of blood nitrogen and serum creatinine which must be excreted. The clinical manifestations ofARF are the decline in glomerular filtration rate (GFR) and the inability of the kidney to excrete the toxic metabolic substances produced in the body. Someof the drugs administered by physicians possess nephrotoxicities and occasionally induce ARF. Therefore, physicians must have vas...
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This study is a preliminary analysis of the prescription behavior of residents in a teaching hospital, with respect to nephrotoxic drugs during a 2-month period. The overdose rate was 3%. Only 5.1% of the doctors were responsible for 51% of the nephrotoxic drug overdoses.
متن کاملInhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling
Antisense oligonucleotide (AON) therapeutics offer new avenues to pursue clinically relevant targets inaccessible with other technologies. Advances in improving AON affinity and stability by incorporation of high affinity nucleotides, such as locked nucleic acids (LNA), have sometimes been stifled by safety liabilities related to their accumulation in the kidney tubule. In an attempt to predict...
متن کاملNephrotoxic Serum Nephritis in Rats
Studies have been carried out to determine the distribution of antigen capable of inducing the formation in rabbits of antibodies nephrotoxic for the rat. The results indicate that the antigen is present both in cortex and medulla of rat kidney. It can be extracted to a limited extent with saline. It is non-dialyzable and destroyed by boiling. The nephrotoxic serum antigen is also present in ra...
متن کاملNephrotoxic Effects of Cadmium
Cadmium is a modern toxic metal and is a by-product of zinc and lead mining and smelting, which are important sources of environmental pollution. In humans, the kidney is recognized as the most critical organ affected by chronic exposure to cadmium. The present study was designed to explore the renotoxic effects of intraperitoneal acute administration of CdCl2 (0.32 mg/kg b.w.) in albino mice. ...
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ژورنال
عنوان ژورنال: DMW - Deutsche Medizinische Wochenschrift
سال: 2005
ISSN: 0012-0472,1439-4413
DOI: 10.1055/s-2005-922037